This depends on the severity of the symptoms and if medicated products have been used previously so its hard to give precise timings as rosacea is a complex skin condition that varies a great deal between different people. For some people the Kalme products work very quickly, within a few days, and for others it takes several weeks.

However as a general guide, after 3-4 weeks most people usually start to see significantly positive results and the products begin to have an accumulative effect.

If used regularly over several months, for many people they help control and manage flare ups and generally significantly improve the skin's condition and fluctuating skin tones on a long-term basis. 

Sadly too often people give up on the Kalme products too quickly before seeing their full benefits, although of course like any product for rosacea (medicated or not), its a very complex skin condition and not all products will work the same for everyone. Its often a matter of trial and error to find out what works for you personally.